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Details on Person Glycoproteins in human tumors often exhibit abnormal glycosy...
| Class:Id | Summation:8858472 |
|---|---|
| _displayName | Glycoproteins in human tumors often exhibit abnormal glycosy... |
| _timestamp | 2016-09-16 15:19:22 |
| created | [InstanceEdit:8858505] Garapati, Phani Vijay, 2016-02-19 |
| literatureReference | [LiteratureReference:8858405] Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells [LiteratureReference:8858520] Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen [LiteratureReference:8878968] Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells |
| modified | [InstanceEdit:8878969] Garapati, Phani Vijay, 2016-07-14 [InstanceEdit:8939161] Jupe, Steve, 2016-09-16 [InstanceEdit:8939227] Jupe, Steve, 2016-09-16 |
| text | Glycoproteins in human tumors often exhibit abnormal glycosylation patters, e.g. certain Lewis structures, TF antigen, Tn antigen and/or their sialylated forms, which creates additional binding sites for glycoreceptors. The C-type lectin domain family 10 member A (CLEC10A/MGL/CD301) is a calcium-type (C-type) lectin glycoreceptor expressed on dendritic cells (DCs) (Suzuki et al. 1996). It recognizes glycoproteins from both altered self and pathogens due to its monosaccharide specificity for galactose (Gal) and N-acetylgalactosamine (GalNAc). CLEC10A specifically binds glycans with terminal GalNAc residues such as Tn antigen (GalNAcalpha-serine/threonine), 6-sulfo-Tn, Lac-di-NAc (Galbeta1,4-GlcNAc) as well as core 5 (GalNAcalpha1-3GalNAcalpha-) and core 6 (GlcNAcbeta1-6GalNAcalpha-) that are expressed in human tumors (Mortezai et al. 2013, van Vliet et al. 2005). CLEC10A on immature human monocyte-derived DCs has been shown to recognize and internalize the three tandem repeat peptides of Mucin-1 carrying Tn (Tn-MUC1) (Denda-Nagai et al. 2010). |
| (summation) | [Reaction:8858500] CLEC10A binds Tn-MUC1 [Homo sapiens] |
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No pathways have been reviewed or authored by Glycoproteins in human tumors often exhibit abnormal glycosy... (8858472)
