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Details on Person UniProt:F7BJB9 Morc3
| Class:Id | ReferenceGeneProduct:8856993 |
|---|---|
| _chainChangeLog | chain:1-942 added on Fri February 12 2016 |
| _displayName | UniProt:F7BJB9 Morc3 |
| _timestamp | 2023-11-03 15:09:38 |
| chain | chain:1-942 |
| checksum | 29EFFF22B7B24C94 |
| comment | FUNCTION Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.ACTIVITY REGULATION Dimerization of the ATPase domain is strictly required for the catalytic activity and binding to double-stranded DNA. Disrupting the interface between ATPase and the CW domains releases autoinhibition since the CW domain sterically impedes binding of the ATPase domain to DNA.SUBUNIT Homodimer. The sumoylated form interacts with PML (via SUMO-interacting motif). Interacts with TP53.SUBCELLULAR LOCATION Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.DOMAIN The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.PTM Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.DISRUPTION PHENOTYPE Lethality occurs at birth or within a day thereafter, for unknown reasons. Embryos at 14.5 dpc are morphologically indistinguishable from wild type (PubMed:17332504). MORC3 deletion leads to increased osteoblast differentiation and altered osteoblastic gene expression through up-regulation of IFN-beta/STAT1 signaling pathway (PubMed:27188231).SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:8856987] Weiser, JD |
| description | recommendedName: fullName evidence="1"MORC family CW-type zinc finger protein 3 alternativeName: fullName evidence="1"Nuclear matrix protein 2 alternativeName: fullName evidence="1"Zinc finger CW-type coiled-coil domain protein 3 |
| geneName | Morc3 Nxp2 Zcwcc3 |
| identifier | F7BJB9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chromosome Coiled coil Immunity Innate immunity Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome RNA-binding Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:8869714] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Morc3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MORC3_MOUSE A6H605 Q4QQR6 Q6A0C2 Q8R0R0 |
| sequenceLength | 942 |
| species | [Species:48892] Mus musculus |
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No pathways have been reviewed or authored by UniProt:F7BJB9 Morc3 (8856993)
