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Details on Person Recruitment of AP-2 complex and clathrin

Class:Id	Reaction:8856808
_displayName	Recruitment of AP-2 complex and clathrin
_doRelease	TRUE
_timestamp	2016-05-19 16:46:27
authored	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8856812] Rothfels, Karen, 2016-02-11
edited	[InstanceEdit:8870660] Rothfels, Karen, 2016-05-10
input	[Complex:167712] AP-2 Complex [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8854795] AAK1 [cytosol] [Homo sapiens] [Complex:8862276] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] [Homo sapiens] [CandidateSet:8863469] NECAPs [cytosol] [Homo sapiens] [Complex:8856809] clathrin triskelion [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8856473] Molecular mechanism and physiological functions of clathrin-mediated endocytosis [LiteratureReference:8856466] Forty Years of Clathrin-coated Vesicles [LiteratureReference:8856472] Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2 [LiteratureReference:8856484] Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2 [LiteratureReference:8868023] Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes [LiteratureReference:8868032] Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis [LiteratureReference:8867986] Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage [LiteratureReference:8856498] The first five seconds in the life of a clathrin-coated pit [LiteratureReference:8856460] Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor micro2 kinase [LiteratureReference:8856488] Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals [LiteratureReference:8856467] Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis [LiteratureReference:8856451] AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin [LiteratureReference:8856490] Phosphorylation of threonine 156 of the mu2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo [LiteratureReference:8863551] Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif [LiteratureReference:8863552] Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics [LiteratureReference:8863535] The NECAP PHear domain increases clathrin accessory protein binding potential [LiteratureReference:8863543] NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis [LiteratureReference:8871075] BRAG2/GEP100/IQSec1 interacts with clathrin and regulates ?5?1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5) [LiteratureReference:8871064] ARFGAP1 promotes AP-2-dependent endocytosis [LiteratureReference:8863700] Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly [LiteratureReference:8871060] ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly [LiteratureReference:8871033] The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes [LiteratureReference:1676172] ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma [LiteratureReference:8871071] ArfGAP1 interacts with coat proteins through tryptophan-based motifs
modified	[InstanceEdit:8862281] Rothfels, Karen, 2016-02-25 [InstanceEdit:8863742] Rothfels, Karen, 2016-03-09 [InstanceEdit:8867764] Rothfels, Karen, 2016-04-16 [InstanceEdit:8868074] Rothfels, Karen, 2016-04-18 [InstanceEdit:8870652] Rothfels, Karen, 2016-05-10 [InstanceEdit:8870663] Rothfels, Karen, 2016-05-10 [InstanceEdit:8871208] Rothfels, Karen, 2016-05-13 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of AP-2 complex and clathrin
output	[Complex:8868048] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8862280] FCHo proteins bind nascent clathrin-coated pit [Homo sapiens] [Reaction:8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Homo sapiens]
regulatedBy	[PositiveRegulation:8871177] Positive regulation by 'ARFGAP1:ARF6:GTP [cytosol]'
releaseDate	2016-06-15
reviewed	[InstanceEdit:8870617] Antonescu, Costin N, 2016-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873439] R-HSA-8856808.4
summation	[Summation:8856807] Recruitment of early acting proteins such as the FCHo and IT...
(hasEvent)	[Pathway:8856828] Clathrin-mediated endocytosis [Homo sapiens]
(precedingEvent)	[Reaction:8856813] AAK1 phosphorylates AP-2 mu subunit at T156 [Homo sapiens] [Reaction:8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Homo sapiens]
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No pathways have been reviewed or authored by Recruitment of AP-2 complex and clathrin (8856808)