Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Neuroplastin (NPTN) is a glycoprotein that belongs to the im...
| Class:Id | Summation:8856400 |
|---|---|
| _displayName | Neuroplastin (NPTN) is a glycoprotein that belongs to the im... |
| _timestamp | 2016-02-17 12:43:34 |
| created | [InstanceEdit:8856410] Jupe, Steve, 2016-02-10 |
| literatureReference | [LiteratureReference:8856434] CD147 immunoglobulin superfamily receptor function and role in pathology [LiteratureReference:8856387] Trafficking and synaptic anchoring of ionotropic inhibitory neurotransmitter receptors [LiteratureReference:8856393] Gephyrin, the enigmatic organizer at GABAergic synapses [LiteratureReference:8856419] Activated radixin is essential for GABAA receptor alpha5 subunit anchoring at the actin cytoskeleton [LiteratureReference:8856402] The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors [LiteratureReference:8856396] The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function [LiteratureReference:8856399] Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss |
| modified | [InstanceEdit:8856449] Jupe, Steve, 2016-02-10 [InstanceEdit:8857948] Jupe, Steve, 2016-02-17 |
| text | Neuroplastin (NPTN) is a glycoprotein that belongs to the immunoglobulin (Ig) superfamily of cell adhesion molecules (CAMs). Together with basigin/CD147 and embigin, NPTN comprises the CD147 family (Iacono et al. 2007). NPTN isoform p65 binds GABAA receptor subunits, co-localizing with alpha1 and alpha2, but not alpha3 subunits at GABAergic synapses and alpha5 subunits at extrasynaptic sites in cultures (Sarto-Jackson et al. 2012). GABAA receptors containing alpha1, 2 or 3 subunits are localized mainly at synaptic sites and interact with the scaffolding protein Gephyrin (GPHN), which anchors the receptor to the underlying postsynaptic complex and prevents their lateral diffusion (Kneussel & Loebrich 2007, Tretter et al. 2012). Receptors containing the alpha5 subunit are mainly extrasynaptic and link to the actin cytoskeleton via Radixin (Loebrich et al. 2006). NPTN p65 co-localization can be at several synaptic sites along the same dendrite, while absent from others. NPTN p65 shRNA caused diffuse alpha2 subunit staining which did not co-localize with vesicular inhibitory aa transporter, a presynaptic marker of GABAergic synapses (Sarto-Jackson et al. 2012). This suggests a functional role for NPTN p65 in regulating the composition and localization of GABAA receptors (Beesley et al. 2014). The absence of NPTN p65 causes early-onset sensorineural hearing loss and prevents normal synaptogenesis in cochleal inner hair cells (IHCs) (Carrott et al. 2016). |
| (summation) | [Reaction:8856390] Nptn binds 2xGabra1,2xGabrb2,Gabrg2:GABA [Rattus norvegicus] [Reaction:8856398] NPTN binds GABA A receptors [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Neuroplastin (NPTN) is a glycoprotein that belongs to the im... (8856400)
