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Details on Person B4GALNT1 dimer transfers GalNAc to gangliosides

Class:Id	Reaction:8856223
_displayName	B4GALNT1 dimer transfers GalNAc to gangliosides
_doRelease	TRUE
_timestamp	2023-10-24 08:19:31
authored	[InstanceEdit:8856225] Jassal, Bijay, 2016-02-09
catalystActivity	[CatalystActivity:8856222] (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity of B4GALNT1 dimer [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:8856225] Jassal, Bijay, 2016-02-09
edited	[InstanceEdit:8856225] Jassal, Bijay, 2016-02-09
input	[DefinedSet:8856243] GD3,GM3,GT3,SM3,LacCer [Golgi membrane] [SimpleEntity:735700] UDP-GalNAc [Golgi lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:8856251] Disulfide bonds of GM2 synthase homodimers. Antiparallel orientation of the catalytic domains [LiteratureReference:8856250] Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia [LiteratureReference:8856240] Expression cloning of beta 1,4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides [LiteratureReference:9845495] Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells [LiteratureReference:9840312] Emerging concepts of ganglioside metabolism
modified	[InstanceEdit:8856253] Jassal, Bijay, 2016-02-09 [InstanceEdit:8856269] Jassal, Bijay, 2016-02-09 [InstanceEdit:8862659] Jassal, Bijay, 2016-02-29 [InstanceEdit:8866934] Jassal, Bijay, 2016-04-05 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9845496] Stephan, Ralf, 2023-10-03 [InstanceEdit:9845508] Stephan, Ralf, 2023-10-04 [InstanceEdit:9851346] Stephan, Ralf, 2023-10-24
name	B4GALNT1 dimer transfers GalNAc to gangliosides
output	[DefinedSet:8856242] GD2,GM2, GA2,GT2,SM2 [Golgi membrane] [SimpleEntity:205687] UDP [Golgi lumen] [SimpleEntity:425969] H+ [Golgi lumen]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2016-06-15
reviewed	[InstanceEdit:8866933] D'Eustachio, Peter, 2016-04-05 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873448] R-HSA-8856223.4
structureModified	[InstanceEdit:9845508] Stephan, Ralf, 2023-10-04
summation	[Summation:8856268] Gangliosides are part of the family of glycosphingolipids an...
(hasEvent)	[Pathway:9840309] Glycosphingolipid biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:9845516] B3GALT4 transfers Gal to gangliosides [Homo sapiens] [BlackBoxEvent:9850731] Vesicles transport GSL from Golgi to plasma membrane [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9853286] Update Tracker - [Reaction:8856223] B4GALNT1 dimer transfers GalNAc to gangliosides - v87:[addLiteratureReference, addOutput, modifyText]
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