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Details on Person HTRA1 hydrolyzes ACAN (Aggrecan)

Class:Id	Reaction:8855825
_displayName	HTRA1 hydrolyzes ACAN (Aggrecan)
_doRelease	TRUE
_timestamp	2016-02-19 18:21:30
authored	[InstanceEdit:8855824] D'Eustachio, Peter, 2016-02-05
catalystActivity	[CatalystActivity:8855862] serine-type endopeptidase activity of HTRA1 trimer [extracellular region]
catalystActivityReference	[CatalystActivityReference:9643184] serine-type endopeptidase activity of HTRA1 trimer [extracellular region] Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:8855824] D'Eustachio, Peter, 2016-02-05
edited	[InstanceEdit:8855824] D'Eustachio, Peter, 2016-02-05
input	[DefinedSet:2318622] Aggrecan [extracellular region] [Homo sapiens] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:8855861] Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo [LiteratureReference:8855826] Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage [LiteratureReference:8855821] HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins [LiteratureReference:8855848] Substrate-induced remodeling of the active site regulates human HTRA1 activity
modified	[InstanceEdit:8855864] D'Eustachio, Peter, 2016-02-05 [InstanceEdit:8856052] D'Eustachio, Peter, 2016-02-08 [InstanceEdit:8856683] D'Eustachio, Peter, 2016-02-11 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HTRA1 hydrolyzes ACAN (Aggrecan)
output	[DefinedSet:8855843] ACAN(17-375) [extracellular region] [Homo sapiens] [DefinedSet:8855819] ACAN(376-2415) [extracellular region] [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8856053] Jupe, Steve, 2016-02-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861215] R-HSA-8855825.3
summation	[Summation:8855832] Extracellular HTRA1 (High-temperature requirement A serine p...
(hasEvent)	[Pathway:1474228] Degradation of the extracellular matrix [Homo sapiens]
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No pathways have been reviewed or authored by HTRA1 hydrolyzes ACAN (Aggrecan) (8855825)