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Details on Person Apolipoprotein C-I (APOC1) is a 6.6 kDa apolipoprotein that ...
| Class:Id | Summation:8855537 |
|---|---|
| _displayName | Apolipoprotein C-I (APOC1) is a 6.6 kDa apolipoprotein that ... |
| _timestamp | 2016-03-30 14:20:34 |
| created | [InstanceEdit:8855542] Jassal, Bijay, 2016-02-04 |
| modified | [InstanceEdit:8855555] Jassal, Bijay, 2016-02-04 [InstanceEdit:8855614] Jassal, Bijay, 2016-02-04 [InstanceEdit:8866303] Jassal, Bijay, 2016-03-30 |
| text | Apolipoprotein C-I (APOC1) is a 6.6 kDa apolipoprotein that is synthesised mainly in the liver but also in other tissues. It is a constituent of triglyceride-rich lipoproteins (around 10% of the protein of VLDLs and 2% of HDLs) that slow the circulatory clearance of triglyceride-rich lipoproteins by a variety of mechanisms. As well as appearing to bind and inhibit triglyceride-rich lipoprotein uptake by the very low-density lipoprotein receptor (VLDLR), it can also binds free fatty acids (FAs) in the circulation, reducing their uptake by cells. Variations in the expression of APOC1 may be a contributing factor in resistance to obesity (Shachter 2001, Westerterp et al. 2007). APOC1 may also be a contributing factor in the development of Alzheimer's disease (Abildayeva et al. 2008). |
| (summation) | [Reaction:8855536] APOC1 binds FAs [Homo sapiens] |
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No pathways have been reviewed or authored by Apolipoprotein C-I (APOC1) is a 6.6 kDa apolipoprotein that ... (8855537)
