Query author contributions in Reactome
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Details on Person Once proprotein convertase subtilisin/kexin type 9 (PCSK9) b...
| Class:Id | Summation:8855133 |
|---|---|
| _displayName | Once proprotein convertase subtilisin/kexin type 9 (PCSK9) b... |
| _timestamp | 2016-02-04 16:24:14 |
| created | [InstanceEdit:8855137] Jassal, Bijay, 2016-02-01 |
| modified | [InstanceEdit:8855542] Jassal, Bijay, 2016-02-04 |
| text | Once proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to very low-density lipoprotein receptor (VLDLR), the resultant complex is internalised via the canonical clathrin-dependent endocytic machinery. This degradation route that does not require ubiquitination of the cytoplasmic tail of the receptor and does not involve proteasomal or autophagy pathways. The PCSK9:VLDLR:Clathrin-coated vesicle complex translocates from the plasma membrane, via endosomes to the lysosomal membrane where the receptor is degraded (Zhang et al. 2007, Poirier et al. 2008). |
| (summation) | [BlackBoxEvent:8855130] VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane [Homo sapiens] |
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No pathways have been reviewed or authored by Once proprotein convertase subtilisin/kexin type 9 (PCSK9) b... (8855133)
