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Details on Person VLDLR:PCSK9 binds Clathrin-coated vesicles

Class:Id	Reaction:8855131
_displayName	VLDLR:PCSK9 binds Clathrin-coated vesicles
_doRelease	TRUE
_timestamp	2016-05-19 16:46:35
authored	[InstanceEdit:8855137] Jassal, Bijay, 2016-02-01
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8855137] Jassal, Bijay, 2016-02-01
edited	[InstanceEdit:8855137] Jassal, Bijay, 2016-02-01
input	[Complex:8855118] VLDL:PCSK9 [plasma membrane] [Homo sapiens] [Complex:177505] Clathrin:AP-2 complex [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8855117] The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 [LiteratureReference:6784740] Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
modified	[InstanceEdit:8862659] Jassal, Bijay, 2016-02-29 [InstanceEdit:8866426] Jassal, Bijay, 2016-04-01 [InstanceEdit:8866932] Jassal, Bijay, 2016-04-05 [InstanceEdit:8866934] Jassal, Bijay, 2016-04-05 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VLDLR:PCSK9 binds Clathrin-coated vesicles
output	[Complex:8855134] VLDL:PCSK9:Clathrin:AP2 [plasma membrane] [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8866933] D'Eustachio, Peter, 2016-04-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873466] R-HSA-8855131.3
summation	[Summation:8855142] Once proprotein convertase subtilisin/kexin type 9 (PCSK9) b...
(hasEvent)	[Pathway:8866427] VLDLR internalisation and degradation [Homo sapiens]
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No pathways have been reviewed or authored by VLDLR:PCSK9 binds Clathrin-coated vesicles (8855131)