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Details on Person p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K

Class:Id	BlackBoxEvent:8854905
_displayName	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
_doRelease	TRUE
_timestamp	2016-05-19 16:47:03
authored	[InstanceEdit:8853613] Jupe, Steve, 2016-01-25
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8854904] Jupe, Steve, 2016-01-29
edited	[InstanceEdit:8869649] Jupe, Steve, 2016-04-28
input	[Complex:8855302] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] [Homo sapiens] [DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8854358] Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation [LiteratureReference:8854365] Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor [LiteratureReference:8854366] Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
modified	[InstanceEdit:8855082] Jupe, Steve, 2016-02-01 [InstanceEdit:8855288] Jupe, Steve, 2016-02-03 [InstanceEdit:8855517] Jupe, Steve, 2016-02-04 [InstanceEdit:8855737] Jupe, Steve, 2016-02-05 [InstanceEdit:8856142] Jupe, Steve, 2016-02-09 [InstanceEdit:8856221] Jupe, Steve, 2016-02-09 [InstanceEdit:8869651] Jupe, Steve, 2016-05-06 [InstanceEdit:8871533] Jupe, Steve, 2016-05-17 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
output	[Complex:8855523] 2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated [Homo sapiens] [BlackBoxEvent:8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8869653] Morales, Daniel, 2016-05-06 [InstanceEdit:8871576] Luo, Wenqin, 2016-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873547] R-HSA-8854905.3
summation	[Summation:8853776] Following recruitment and phosphorylation of GAB1 or GAB2 to...
(hasEvent)	[Pathway:8853659] RET signaling [Homo sapiens]
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No pathways have been reviewed or authored by p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (8854905)