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Details on Person Interleukin-19 (IL19) binds a heterodimeric receptor complex...

Class:IdSummation:8854698
_displayNameInterleukin-19 (IL19) binds a heterodimeric receptor complex...
_timestamp2017-07-05 08:03:27
created[InstanceEdit:8854660] Jupe, Steve, 2016-01-28
literatureReference[LiteratureReference:448739] Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions
[LiteratureReference:8854681] Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines
[LiteratureReference:8854646] The IL-20 subfamily of cytokines--from host defence to tissue homeostasis
[LiteratureReference:9006691] Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20
[LiteratureReference:8854666] Interleukin 20: discovery, receptor identification, and role in epidermal function
[LiteratureReference:9006696] Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)
modified[InstanceEdit:8986386] Duenas, Corina, 2017-04-26
[InstanceEdit:8986399] Duenas, Corina, 2017-04-26
[InstanceEdit:8987431] Duenas, Corina, 2017-05-05
[InstanceEdit:9005363] Duenas, Corina, 2017-05-08
[InstanceEdit:9005492] Duenas, Corina, 2017-05-09
[InstanceEdit:9006705] Duenas, Corina, 2017-05-18
[InstanceEdit:9009145] Duenas, Corina, 2017-06-15
[InstanceEdit:9009263] Duenas, Corina, 2017-06-16
[InstanceEdit:9009474] Duenas, Corina, 2017-06-19
[InstanceEdit:9010848] Duenas, Corina, 2017-06-28
[InstanceEdit:9011370] Jupe, Steve, 2017-06-30
[InstanceEdit:9011709] Jupe, Steve, 2017-07-05
textInterleukin-19 (IL19) binds a heterodimeric receptor complex that consists of Interleukin-20 Receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB).
Interleukin-20 receptor A (IL20RA) and Interleukin-20 receptor B (IL20RB) form a receptor complex for Interleukin-19 (IL19) (and Interleukin-20 (IL20) and Interleukin-24 (IL24)) (Gallagher et al. 2000, Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014, Pletnev et al. 2003).
This is a black box event because it is not clear whether the dimeric receptor can form in the absence of ligand.
(summation)[BlackBoxEvent:448728] IL19 binds IL20RA:JAK1:IL20RB [Homo sapiens]
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