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Details on Person The protein levels of aurora kinase A (AURKA) during mitotic...
| Class:Id | Summation:8854514 |
|---|---|
| _displayName | The protein levels of aurora kinase A (AURKA) during mitotic... |
| _timestamp | 2016-05-25 17:35:24 |
| created | [InstanceEdit:8854515] Orlic-Milacic, Marija, 2016-01-27 |
| modified | [InstanceEdit:8854532] Orlic-Milacic, Marija, 2016-01-27 [InstanceEdit:8874668] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8874672] Orlic-Milacic, Marija, 2016-05-25 |
| text | The protein levels of aurora kinase A (AURKA) during mitotic entry and in early mitosis can be reduced by the action of the SCF-FBXL7 E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXL7 subunits. FBXL7 is the substrate recognition subunit of the SCF-FBXL7 complex that associates with the centrosome-bound AURKA, promoting its ubiquitination and proteasome-mediated degradation. Overexpression of FBXL7 results in G2/M cell cycle arrest and apoptosis (Coon et al. 2011). FBXL7 protein levels are down-regulated by the action of the SCF-FBXL18 E3 ubiquitin ligase complex, consisting of SKP1, CUL1, RBX1 and the substrate recognition subunit FBXL18. FBXL18 binds to the FQ motif of FBXL7, targeting it for ubiquitination and proteasome-mediated degradation, counteracting its pro-apoptotic activity (Liu et al. 2015). Cell cycle stage-dependency of down-regulation of FBXL7 by FBXL18 is unknown. |
| (summation) | [Pathway:8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis [Homo sapiens] |
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