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Details on Person Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase

Class:Id	LiteratureReference:8854366
_displayName	Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
_timestamp	2016-01-27 10:35:50
author	[Person:8854354] Besset, V [Person:8854378] Scott, R P [Person:8853744] Ib��ez, C F
created	[InstanceEdit:8854347] Jupe, Steve, 2016-01-27
journal	J. Biol. Chem.
pages	39159-66
pubMedIdentifier	10995764
title	Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
volume	275
year	2000
(literatureReference)	[Reaction:8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 [Homo sapiens] [BlackBoxEvent:8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated [Homo sapiens] [BlackBoxEvent:8853793] p-5Y-RET complexes bind GRB2 [Homo sapiens] [BlackBoxEvent:8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 [Homo sapiens] [Reaction:8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 [Homo sapiens] [BlackBoxEvent:8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K [Homo sapiens] [BlackBoxEvent:8854981] SHC1 in the RET complex is phosphorylated [Homo sapiens] [Reaction:8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 [Homo sapiens] [Summation:8853735] RET undergoes trans-autophosphorylation on specific tyrosine... [Summation:8853759] Grb-associated binder (GAB) proteins are a family of docking... List all 18 refering instances
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