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Details on Person RAB35 is a Rab protein with both plasma membrane and endosom...

Class:IdSummation:8854301
_displayNameRAB35 is a Rab protein with both plasma membrane and endosom...
_timestamp2016-10-21 12:01:54
created[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
literatureReference[LiteratureReference:8854203] Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins
[LiteratureReference:8854200] Rab35 controls actin bundling by recruiting fascin as an effector protein
[LiteratureReference:8854201] Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis
[LiteratureReference:8854342] An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis
[LiteratureReference:8854273] TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes
[LiteratureReference:8877651] Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein
[LiteratureReference:8942928] Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway
[LiteratureReference:8877653] The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes
[LiteratureReference:8877649] Rab35 GTPase: a central regulator of phosphoinositides and F-actin in endocytic recycling and beyond
modified[InstanceEdit:8942930] Garapati, Phani Vijay, 2016-10-21
[InstanceEdit:8942936] Garapati, Phani Vijay, 2016-10-21
textRAB35 is a Rab protein with both plasma membrane and endosomal membrane localization, where it controls vesicular trafficking. RAB35 regulates the endocytic recycling of numerous protein cargoes, is involved in the recycling of synaptic vesicles (Uytterhoeven et al. 2011; Allaire et al. 2010, Sato et al. 2008, Sheehan et al. 2106, Klinkert & Echard 2016), controls the fusion of exosomes (Hsu et al. 2010), and regulates the actin cytoskeleton (Zhang et al. 2009). At least five different members of the TBC protein family are GAPs for Rab35. The three members of TBC1D10A-C family (also known as EPI64A-C) are identified to have Rab35-specific GAP activity and regulate exosome secretion (Hsu et al. 2010). TBC1D10 family members are also involved in the endocytic recycling and prevent cytokinesis (Kouranti et al. 2006, Chesneau et al. 2012).
TBC1D13 was identified as a specific GAP for Rab35 and observed to act as a potent inhibitor of insulin-stimulated GLUT4 translocation (Davey et al. 2012). TBC1D24 is a homolog of a Drosophila protein called skywalker, which has been shown to exhibit GAP activity towards Rab35 (Uytterhoeven et al. 2011).
(summation)[Reaction:8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 [Homo sapiens]
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