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Details on Person Formation of the SCF-FBXL7 complex

Class:Id	Reaction:8854052
_displayName	Formation of the SCF-FBXL7 complex
_doRelease	TRUE
_timestamp	2016-08-08 18:24:32
authored	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
edited	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
goBiologicalProcess	[GO_BiologicalProcess:263741] SCF complex assembly
input	[EntityWithAccessionedSequence:8854032] FBXL7 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174150] SKP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174230] CUL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180582] RBX1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8853499] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
modified	[InstanceEdit:8854793] Orlic-Milacic, Marija, 2016-01-28 [InstanceEdit:8874677] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933630] Orlic-Milacic, Marija, 2016-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of the SCF-FBXL7 complex
output	[Complex:8854030] SKP1:CUL1:RBX1:FBXL7 [cytosol] [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8874675] Grant, Rhys, 2016-05-13 [InstanceEdit:8874673] Lindon, Catherine, 2016-05-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8911955] R-HSA-8854052.2
summation	[Summation:8854047] FBXL7 associates with SKP1, CUL1 and RBX1 to form the SCF E3...
(hasEvent)	[Pathway:8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis [Homo sapiens]
(precedingEvent)	[Reaction:8853496] SCF:FBXL7 binds AURKA [Homo sapiens]
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No pathways have been reviewed or authored by Formation of the SCF-FBXL7 complex (8854052)