Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person SCF-FBXL18 ubiquitinates FBXL7

Class:Id	Reaction:8854051
_displayName	SCF-FBXL18 ubiquitinates FBXL7
_doRelease	TRUE
_timestamp	2022-02-08 21:54:36
authored	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
catalystActivity	[CatalystActivity:8854055] ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643346] ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol] F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
edited	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
goBiologicalProcess	[GO_BiologicalProcess:160433] SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
input	[EntityWithAccessionedSequence:8854032] FBXL7 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8854057] F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7
modified	[InstanceEdit:8854068] Orlic-Milacic, Marija, 2016-01-26 [InstanceEdit:8854793] Orlic-Milacic, Marija, 2016-01-28 [InstanceEdit:8874677] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933630] Orlic-Milacic, Marija, 2016-08-08 [InstanceEdit:9634786] Rothfels, Karen, 2019-01-15 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9764023] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9764050] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SCF-FBXL18 ubiquitinates FBXL7
negativePrecedingEvent	[NegativePrecedingEvent:9764022] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53 [NegativePrecedingEvent:9764048] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [NegativePrecedingEvent:9764047] Futile Cycle: Proteasome-mediated degradation of PolyUb-FBXL7
output	[EntityWithAccessionedSequence:8854053] PolyUb-K109-FBXL7 [cytosol] [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8874675] Grant, Rhys, 2016-05-13 [InstanceEdit:8874673] Lindon, Catherine, 2016-05-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8880860] R-HSA-8854051.5
summation	[Summation:8854056] FBXL18, a substrate recognition subunit of the SCF E3 ubiqui...
(hasEvent)	[Pathway:8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8854071] Proteasome-mediated degradation of PolyUb-FBXL7 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778543] Update Tracker - [Reaction:8854051] SCF-FBXL18 ubiquitinates FBXL7 - v68:[add_removeInput]
[Change default viewing format]

No pathways have been reviewed or authored by SCF-FBXL18 ubiquitinates FBXL7 (8854051)