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Details on Person Proteasome degrades AURKA ubiquitinated by SCF-FBXL7

Class:Id	BlackBoxEvent:8854044
_displayName	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
_doRelease	TRUE
_timestamp	2019-01-15 13:51:25
authored	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8854045] Orlic-Milacic, Marija, 2016-01-26
edited	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
goBiologicalProcess	[GO_BiologicalProcess:422949] negative regulation of G2/M transition of mitotic cell cycle
input	[Complex:8854038] SCF-FBXL7:PolyUb-AURKA [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8853499] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
modified	[InstanceEdit:8854792] Orlic-Milacic, Marija, 2016-01-28 [InstanceEdit:8854793] Orlic-Milacic, Marija, 2016-01-28 [InstanceEdit:8874670] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8874677] Orlic-Milacic, Marija, 2016-05-25 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933630] Orlic-Milacic, Marija, 2016-08-08 [InstanceEdit:9634780] Rothfels, Karen, 2019-01-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
output	[Complex:8854030] SKP1:CUL1:RBX1:FBXL7 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8854041] SCF-FBXL7 ubiquitinates AURKA [Homo sapiens] [Reaction:8853496] SCF:FBXL7 binds AURKA [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8874675] Grant, Rhys, 2016-05-13 [InstanceEdit:8874673] Lindon, Catherine, 2016-05-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8921280] R-HSA-8854044.3
summation	[Summation:8854043] Upon ubiquitination by the SCF-FBXL7 E3 ubiquitin ligase com...
(hasEvent)	[Pathway:8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764040] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [NegativePrecedingEvent:9764043] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [NegativePrecedingEvent:9764046] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [NegativePrecedingEvent:9764048] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
(updatedInstance)	[_UpdateTracker:9778055] Update Tracker - [BlackBoxEvent:8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 - v68:[add_removeOutput]
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