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Details on Person SCF-FBXL7 ubiquitinates AURKA

Class:IdReaction:8854041
_displayNameSCF-FBXL7 ubiquitinates AURKA
_doReleaseTRUE
_timestamp2022-02-08 21:54:38
authored[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
catalystActivity[CatalystActivity:8854036] ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol]
catalystActivityReference[CatalystActivityReference:9643432] ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
compartment[Compartment:70101] cytosol
created[InstanceEdit:8854035] Orlic-Milacic, Marija, 2016-01-26
edited[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
goBiologicalProcess[GO_BiologicalProcess:422949] negative regulation of G2/M transition of mitotic cell cycle
input[Complex:8854031] SCF-FBXL7:AURKA [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8853499] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
modified[InstanceEdit:8854046] Orlic-Milacic, Marija, 2016-01-26
[InstanceEdit:8854792] Orlic-Milacic, Marija, 2016-01-28
[InstanceEdit:8874677] Orlic-Milacic, Marija, 2016-05-25
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8933630] Orlic-Milacic, Marija, 2016-08-08
[InstanceEdit:9634787] Rothfels, Karen, 2019-01-15
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9764023] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764050] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSCF-FBXL7 ubiquitinates AURKA
negativePrecedingEvent[NegativePrecedingEvent:9764018] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53
[NegativePrecedingEvent:9764040] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
[NegativePrecedingEvent:9764041] Futile Cycle: Proteasome-mediated degradation of PolyUb-FBXL7
output[Complex:8854038] SCF-FBXL7:PolyUb-AURKA [cytosol] [Homo sapiens]
precedingEvent
releaseDate2016-09-19
reviewed[InstanceEdit:8874675] Grant, Rhys, 2016-05-13
[InstanceEdit:8874673] Lindon, Catherine, 2016-05-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8883698] R-HSA-8854041.5
summation[Summation:8854037] The SCF-FBXL7 E3 ubiquitin ligase complex, composed of SKP1,...
(hasEvent)[Pathway:8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis [Homo sapiens]
(precedingEvent)[BlackBoxEvent:8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778176] Update Tracker - [Reaction:8854041] SCF-FBXL7 ubiquitinates AURKA - v68:[add_removeInput]
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No pathways have been reviewed or authored by SCF-FBXL7 ubiquitinates AURKA (8854041)
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