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Details on Person CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm]

Class:Id	Complex:8853944
_displayName	CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm]
_timestamp	2016-12-07 19:19:59
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8853954] Orlic-Milacic, Marija, 2016-01-25
hasComponent	[EntityWithAccessionedSequence:8853953] CCND1 gene [nucleoplasm] [Homo sapiens] [Complex:8951439] CTNNB1:TCF7L2,LEF1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3451168] CTNNB1 [nucleoplasm] [Homo sapiens] [DefinedSet:8853943] TCF7L2,LEF1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8853942] Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells [LiteratureReference:8853951] The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8951448] Orlic-Milacic, Marija, 2016-12-02 [InstanceEdit:8951525] Orlic-Milacic, Marija, 2016-12-07
name	CTNNB1:TCF7L2,LEF1:CCND1 Gene CTNNB1:TCF4,LEF1:CCND1 Gene
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8922793] R-HSA-8853944.1
(input)	[Reaction:8853965] VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 [Homo sapiens]
(output)	[Reaction:8951442] CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter [Homo sapiens]
(regulator)	[PositiveGeneExpressionRegulation:8853948] Positive gene expression regulation by 'CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8951440] Positive gene expression regulation by 'CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm]'
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No pathways have been reviewed or authored by CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm] (8853944)