Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Following recruitment and phosphorylation of GAB1 or GAB2 to...

Class:IdSummation:8853776
_displayNameFollowing recruitment and phosphorylation of GAB1 or GAB2 to...
_timestamp2016-04-26 15:15:29
created[InstanceEdit:8853732] Jupe, Steve, 2016-01-25
literatureReference[LiteratureReference:8854358] Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
[LiteratureReference:8854365] Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor
[LiteratureReference:8854366] Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
[LiteratureReference:8855276] A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners
[LiteratureReference:8855279] Phosphatidylinositol 3-kinase
[LiteratureReference:8855283] Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit
[LiteratureReference:437174] Purification and characterization of phosphoinositide 3-kinase from rat liver
[LiteratureReference:188537] Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
[LiteratureReference:188658] The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway
[LiteratureReference:8855307] Grb2 associated binder 2 couples B-cell receptor to cell survival
modified[InstanceEdit:8855082] Jupe, Steve, 2016-02-01
[InstanceEdit:8855091] Jupe, Steve, 2016-02-01
[InstanceEdit:8855288] Jupe, Steve, 2016-02-03
[InstanceEdit:8855517] Jupe, Steve, 2016-02-04
[InstanceEdit:8855565] Jupe, Steve, 2016-02-04
[InstanceEdit:8856142] Jupe, Steve, 2016-02-09
[InstanceEdit:8857590] Jupe, Steve, 2016-02-15
[InstanceEdit:8869243] Jupe, Steve, 2016-04-26
textFollowing recruitment and phosphorylation of GAB1 or GAB2 to the RET complex, it binds the p85 subunit of p85-containing PI3 kinase (p85-PI3K), resulting in its activation (Murakami et al. 1999, Hayashi et al. 2000, Besset et al. 2000). p85-PI3K consists of a p85 adaptor subunit, which contains one Src homology 3 (SH3) and two Src homology 2 (SH2) domains, and a p110 subunit that has catalytic activity (Kapeller & Cantley 1994). These subunits are tightly associated (Carpenter et al. 1990). Though p85-PI3K can be phosphorylated, it is binding of the p85 SH2 domains that activates the enzyme (Rordorf-Nikolic et al. 1995).

GAB2 has three tyrosine residues, Y452, Y476 and Y584, which are involved in p85-PI3K binding (Crouin et al. 2001, Maus et al. 2009). GAB1 also becomes tyrosine phosphorylated and directly associates with p85 when transducing signals from receptor tyrosine kinases to p85 (Holgado-Madruga et al. 1997, Mattoon et al. 2004). There are three potential binding sites for p85 on GAB1 (Y447, Y472, and Y589) (Holgado-Madruga et al. 1997). Phosphorylation at these sites in GAB1 is represented in this reaction as a likely prerequisite for p85 binding, but this is not experimentally confirmed, hence this reaction is displayed as an uncertain event.
(summation)[BlackBoxEvent:8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Following recruitment and phosphorylation of GAB1 or GAB2 to... (8853776)
Follow Reactome