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Details on Person It is widely accepted that RET undergoes dimerization and tr...

Class:IdSummation:8853768
_displayNameIt is widely accepted that RET undergoes dimerization and tr...
_timestamp2016-04-26 15:15:43
created[InstanceEdit:8853732] Jupe, Steve, 2016-01-25
literatureReference[LiteratureReference:8853828] Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
[LiteratureReference:8853836] GDNF family neurotrophic factor signaling: four masters, one servant?
[LiteratureReference:8853838] The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation
[LiteratureReference:8853846] Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation
[LiteratureReference:8853833] The GDNF family: signalling, biological functions and therapeutic value
[LiteratureReference:8854855] Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations
modified[InstanceEdit:8853813] Jupe, Steve, 2016-01-25
[InstanceEdit:8854864] Jupe, Steve, 2016-01-29
[InstanceEdit:8855737] Jupe, Steve, 2016-02-05
[InstanceEdit:8855782] Jupe, Steve, 2016-02-05
[InstanceEdit:8856227] Jupe, Steve, 2016-02-09
[InstanceEdit:8857590] Jupe, Steve, 2016-02-15
[InstanceEdit:8864966] Jupe, Steve, 2016-03-17
[InstanceEdit:8869243] Jupe, Steve, 2016-04-26
textIt is widely accepted that RET undergoes dimerization and transphosphorylation following Glial cell line-derived neurotrophic factor (GDNF) binding to the GDNF-family receptor:RET complex. Transphosphorylation of specific tyrosine residues is a prerequisite for activation of RET tyrosine kinase activity and downstream signaling (Santoro et al. 1995, Airaksinen et al. 1999, Takeda et al. 2001, Leppänen et al. 2004). However, self-association of RET in the absence of GDNF has been reported and may contribute to the mechanism of RET activation (Kjaer et al. 2006). The stoichiometry and kinetics of ligand-receptor complex formation are not well understood. It is assumed that all GDNF family of ligands (GFL) members interact with their cognate co-receptor and activate RET in a similar manner to GDNF (Airaksinen & Saarma 2002).
(summation)[Reaction:8853762] RET dimerizes [Homo sapiens]
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