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Details on Person SCF:FBXL7 binds AURKA

Class:IdReaction:8853496
_displayNameSCF:FBXL7 binds AURKA
_doReleaseTRUE
_timestamp2022-02-08 21:54:42
authored[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
compartment[Compartment:70101] cytosol
created[InstanceEdit:8853501] Orlic-Milacic, Marija, 2016-01-22
edited[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
goBiologicalProcess[GO_BiologicalProcess:422949] negative regulation of G2/M transition of mitotic cell cycle
input[Complex:8854030] SKP1:CUL1:RBX1:FBXL7 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:174254] AURKA [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8853499] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
modified[InstanceEdit:8854034] Orlic-Milacic, Marija, 2016-01-26
[InstanceEdit:8854054] Orlic-Milacic, Marija, 2016-01-26
[InstanceEdit:8854793] Orlic-Milacic, Marija, 2016-01-28
[InstanceEdit:8874670] Orlic-Milacic, Marija, 2016-05-25
[InstanceEdit:8874677] Orlic-Milacic, Marija, 2016-05-25
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8933630] Orlic-Milacic, Marija, 2016-08-08
[InstanceEdit:9764017] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764050] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSCF:FBXL7 binds AURKA
negativePrecedingEvent[NegativePrecedingEvent:9764015] Futile Cycle: AURKA phosphorylates PHLDA1
[NegativePrecedingEvent:9764043] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
output[Complex:8854031] SCF-FBXL7:AURKA [cytosol] [Homo sapiens]
precedingEvent
releaseDate2016-09-19
reviewed[InstanceEdit:8874675] Grant, Rhys, 2016-05-13
[InstanceEdit:8874673] Lindon, Catherine, 2016-05-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8912093] R-HSA-8853496.3
summation[Summation:8854029] FBXL7, a component of the SCF E3 ubiquitin ligase complex, a...
(hasEvent)[Pathway:8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis [Homo sapiens]
(precedingEvent)[Reaction:8854041] SCF-FBXL7 ubiquitinates AURKA [Homo sapiens]
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No pathways have been reviewed or authored by SCF:FBXL7 binds AURKA (8853496)