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Details on Person TPX2 binds AURKA at centrosomes

Class:IdReaction:8853405
_displayNameTPX2 binds AURKA at centrosomes
_doReleaseTRUE
_timestamp2016-02-22 13:42:26
authored[InstanceEdit:8854515] Orlic-Milacic, Marija, 2016-01-27
compartment[Compartment:70101] cytosol
created[InstanceEdit:8853411] Orlic-Milacic, Marija, 2016-01-22
edited[InstanceEdit:8854515] Orlic-Milacic, Marija, 2016-01-27
input[Complex:2574827] Centrosome:AURKA [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:8853407] TPX2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:8861624] HMMR [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:8853412] Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
[LiteratureReference:8861615] Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity
[LiteratureReference:8861611] XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly
[LiteratureReference:8861620] Microtubule nucleation in mitosis by a RanGTP-dependent protein complex
modified[InstanceEdit:8857947] Orlic-Milacic, Marija, 2016-02-17
[InstanceEdit:8858152] Orlic-Milacic, Marija, 2016-02-17
[InstanceEdit:8858169] Orlic-Milacic, Marija, 2016-02-17
[InstanceEdit:8861621] Orlic-Milacic, Marija, 2016-02-19
[InstanceEdit:8861625] Orlic-Milacic, Marija, 2016-02-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTPX2 binds AURKA at centrosomes
output[Complex:8853414] Centrosome:AURKA:TPX2:HMMR [cytosol] [Homo sapiens]
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8857945] Chen, Helen, 2016-02-16
[InstanceEdit:8857944] Maxwell, Christopher A, 2016-02-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8861855] R-HSA-8853405.2
summation[Summation:8853400] TPX2 binds to aurora kinase A (AURKA) at centrosomes. The fi...
(hasEvent)[Pathway:8854518] AURKA Activation by TPX2 [Homo sapiens]
(precedingEvent)[Reaction:8853419] TPX2 promotes AURKA autophosphorylation [Homo sapiens]
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No pathways have been reviewed or authored by TPX2 binds AURKA at centrosomes (8853405)