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Details on Person FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling

Class:Id	Reaction:8853320
_displayName	FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling
_doRelease	TRUE
_timestamp	2016-02-19 18:21:39
authored	[InstanceEdit:8851707] Rothfels, Karen, 2016-01-08
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8853327] Rothfels, Karen, 2016-01-22
disease	[Disease:2011822] acrocephalosyndactylia
edited	[InstanceEdit:8851707] Rothfels, Karen, 2016-01-08
entityFunctionalStatus	[EntityFunctionalStatus:8853299] gain_of_function of FGFR2 IIIa TM [extracellular region]
inferredFrom	[Reaction:8853328] Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors [Homo sapiens]
input	[EntityWithAccessionedSequence:8851703] FGFR2 IIIa TM [extracellular region] [Homo sapiens] [DefinedSet:8851713] FGF1,2 [extracellular region] [Homo sapiens] [DefinedSet:8851704] FGFR2b, FGFR2c [plasma membrane] [Homo sapiens] [SimpleEntity:190915] HS [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:8851693] Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model
modified	[InstanceEdit:8853867] Rothfels, Karen, 2016-01-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling
output	[Complex:8853189] FGFR2IIIa TM:FGF1,2:FGFR2b, FGFR2c [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8851710] Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8853855] Grose, Richard P, 2016-01-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861235] R-HSA-8853320.2
summation	[Summation:8853074] By BIAcore assay, FGFR2 IIIa TM has been shown to bind FGF1,...
(hasEvent)	[Pathway:8851708] Signaling by FGFR2 IIIa TM [Homo sapiens]
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