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Details on Person EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane]

Class:Id	EntityWithAccessionedSequence:8853122
_displayName	EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane]
_timestamp	2023-04-02 09:55:03
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8853143] Rothfels, Karen, 2016-01-21
disease	[Disease:1500576] breast cancer
endCoordinate	186
hasModifiedResidue	[FragmentReplacedModification:9024315] Replacement of residues 186 to 186 by MVSLKRRIELTVEYPWRCGALSPTSNCRTG [FragmentInsertionModification:8853114] Insertion of residues 1 to 822 at 187 from UniProt:P11362 FGFR1 [ModifiedResidue:2011867] O4'-phospho-L-tyrosine at 463 [ModifiedResidue:2011863] O4'-phospho-L-tyrosine at 583 [ModifiedResidue:2011864] O4'-phospho-L-tyrosine at 585 [ModifiedResidue:2011862] O4'-phospho-L-tyrosine at 653 [ModifiedResidue:2011865] O4'-phospho-L-tyrosine at 654 [ModifiedResidue:2011860] O4'-phospho-L-tyrosine at 730 [ModifiedResidue:1838976] O4'-phospho-L-tyrosine at 766 [ModifiedResidue:2011859] O4'-phospho-L-tyrosine at 776
literatureReference	[LiteratureReference:8852972] Identification of targetable FGFR gene fusions in diverse cancers
modified	[InstanceEdit:9024317] Rothfels, Karen, 2017-10-03 [InstanceEdit:9832529] Orlic-Milacic, Marija, 2023-04-02
name	EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) ERLIN2(1-186)-p-8Y FGFR1(c.-88-p.822) fusion
referenceEntity	[ReferenceGeneProduct:87246] UniProt:O94905 ERLIN2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8860515] R-HSA-8853122.3
startCoordinate	1
(hasComponent)	[Complex:8853166] ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion dimer [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9898282] Update Tracker - [EntityWithAccessionedSequence:8853122] EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] - v63:[add_removeHasModifiedResidue] [_UpdateTracker:9905892] Update Tracker - [EntityWithAccessionedSequence:8853122] EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] - v85:[modifyEndCoordinate, modifyName]
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No pathways have been reviewed or authored by EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (8853122)