Query author contributions in Reactome
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Details on Person C7 recruitment of C7 results in a weak association of C5b:C6...
| Class:Id | Summation:8852730 |
|---|---|
| _displayName | C7 recruitment of C7 results in a weak association of C5b:C6... |
| _timestamp | 2016-01-20 15:08:35 |
| created | [InstanceEdit:8852733] Jupe, Steve, 2016-01-20 |
| literatureReference | [LiteratureReference:8852748] The membrane attack complex of complement |
| text | C7 recruitment of C7 results in a weak association of C5b:C6:C7 with the target cell membrane, through a poorly characterized molecular mechanism (Muller -Eberhard et al. 1986). C5b and C6 remains loosely bound to C3b until C5b binds to C7 and induces it to undergo a hydrophilic-amphiphilic transition. Hydrophobic binding regions for phospholipid are thereby exposed, and the trimolecular complex is endowed with a metastable membrane binding site. Membranebound C5b-7 inflicts no harm on a cell but marks it for further assault. |
| (summation) | [Reaction:173720] C5b:C6:C7 translocates to the plasma membrane [Homo sapiens] |
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No pathways have been reviewed or authored by C7 recruitment of C7 results in a weak association of C5b:C6... (8852730)
