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Details on Person Recruitment of the C8 trimeric complex is mediated by the C8...

Class:Id	Summation:8852726
_displayName	Recruitment of the C8 trimeric complex is mediated by the C8...
_timestamp	2016-01-20 15:08:33
created	[InstanceEdit:8852733] Jupe, Steve, 2016-01-20
literatureReference	[LiteratureReference:8852762] Role of the beta subunit in interaction of the eighth component of human complement with the membrane-bound cytolytic complex [LiteratureReference:8852737] Evidence of direct insertion of terminal complement proteins into cell membrane bilayers during cytolysis. Labeling by a photosensitive membrane probe reveals a major role for the eighth and ninth components [LiteratureReference:8852728] Membrane pore formation by human complement: functional importance of the transmembrane β-hairpin (TMH) segments of C8α and C9 [LiteratureReference:8852749] Lysis of tumor cells by antibody and complement. VII. Complement-dependent 86Rb release--a nonlethal event? [LiteratureReference:8852744] Membrane attack by complement: the assembly and biology of terminal complement complexes [LiteratureReference:8852755] Killing of human melanoma cells by the membrane attack complex of human complement as a function of its molecular composition [LiteratureReference:8852741] Mechanisms of signal transduction activated by sublytic assembly of terminal complement complexes on nucleated cells [LiteratureReference:8852743] Cytolysis of nucleated cells by complement: cell death displays multi-hit characteristics
text	Recruitment of the C8 trimeric complex is mediated by the C8 beta chain (Monahan & Sodetz 1981). Binding enables C8 to undergo necessary conformational rearrangements that allow the C8 alpha chain to penetrate into the hydrophobic core of the lipid bilayer (Stecket et al. 1983, Weiland et al. 2014), firmly anchoring the C5b:C6:C7:C8 complex to the target cell membrane. A functional membrane pore can be formed by the C5b:C6:C7:C8 complex (Boyle et al. 1976, Tegla et al. 2011). These pores are small and unstable but can cause cell lysis if present in sufficient number (Martin et al. 1987). They also increase cytosolic free Ca2+ concentration and thereby stimulate signalling pathways (Koski et al. 1983, Niculescu & Rus 2001).
(summation)	[Reaction:173723] C8 binds C5b:C6:C7 [Homo sapiens]
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