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Details on Person Expression of the NBPF1 mRNA is repressed in response to TNF...
| Class:Id | Summation:8852659 |
|---|---|
| _displayName | Expression of the NBPF1 mRNA is repressed in response to TNF... |
| _timestamp | 2016-01-19 21:17:41 |
| created | [InstanceEdit:8852660] Orlic-Milacic, Marija, 2016-01-19 |
| literatureReference | [LiteratureReference:8852643] A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes [LiteratureReference:8852653] NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest [LiteratureReference:8852670] Constitutively active NFkappa B is required for the survival of S-type neuroblastoma [LiteratureReference:8852667] Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in high risk neuro-blastoma, with cell cycle and protein analyte correlates [LiteratureReference:8852598] A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution [LiteratureReference:8852611] NBPF is a potential DNA-binding transcription factor that is directly regulated by NF-κB |
| modified | [InstanceEdit:8852675] Orlic-Milacic, Marija, 2016-01-19 [InstanceEdit:8852676] Orlic-Milacic, Marija, 2016-01-19 |
| text | Expression of the NBPF1 mRNA is repressed in response to TNF-alpha stimulation, presumably via NF-kappa B (NFKB) binding to NFKB response elements at the NBPF1 gene locus. Expression of NBPF1 increases in response to siRNA-mediated downregulation of the NFKB complex subunit RELA (p65) (Zhou et al. 2013). The NFKB complex is constitutively activated in neuroblastoma (Bian et al. 2002, Brown et al. 2007), while a constitutive translocation in neuroblastoma that involves the NBPF1 and ACCN1 genes results in down-regulation of NBPF1 levels (Vandepoele et al. 2008). NBPF1 localizes to the cytosol (Vandepoele et al. 2005) but is predicted to contain a nuclear localization signal (NLS) and may also localize to the nucleus (Zhou et al. 2013). NBPF1 is a putative tumor suppressor gene that inhibits anchorage-independent growth (Vandepoele 2008), and may be involved in TP53 (p53) and CDKNA1 (p21) - mediated cell cycle arrest in some cellular contexts (Andries et al. 2015). |
| (summation) | [BlackBoxEvent:8852655] NFKB complex inhibits NBPF1 expression [Homo sapiens] |
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