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Details on Person Clusterin is a dimer of two fragments of the same translatio...
| Class:Id | Summation:8852572 |
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| _displayName | Clusterin is a dimer of two fragments of the same translatio... |
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| _timestamp | 2016-01-26 14:38:31 |
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| created | [InstanceEdit:8852566] Jupe, Steve, 2016-01-19 |
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| literatureReference | [LiteratureReference:8852582] Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9
[LiteratureReference:8852584] Assignment of a human serum glycoprotein SP-40,40 gene (CLI) to chromosome 8
[LiteratureReference:8852570] Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid
[LiteratureReference:8852583] A serum protein SP40,40 modulates the formation of membrane attack complex of complement on erythrocytes
[LiteratureReference:8852581] SP-40,40 is an inhibitor of C5b-6-initiated haemolysis |
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| modified | [InstanceEdit:8853941] Shamovsky, Veronica, 2016-01-25
[InstanceEdit:8854027] Jupe, Steve, 2016-01-26 |
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| text | Clusterin is a dimer of two fragments of the same translation product, which are disulfide bonded by five cysteines on each peptide (Tobe et al. 1991). It is able to modulate the terminal complement cascade in vitro and prevent cellular lysis by the membrane attack complex (MAC), C5b-9. Clusterin forms complexes with C5b:C6:C7, or C5b:C6:C7:C8 or C5b:C6:C7:C8:C9, as the proteins assemble into the amphiphilic MAC. Clusterin binding renders the complexes soluble and lytically inactive (Jenne & Tschopp 1989, Choi et al. 1989, Murphy et al. 1989, Tschopp et al. 1993). |
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| (summation) | [Reaction:8852580] Clusterin binds C5b-C7, C8, C9 [Homo sapiens] |
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