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Details on Person Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends

Class:Id	Reaction:8852306
_displayName	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends
_doRelease	TRUE
_timestamp	2025-08-18 11:34:36
authored	[InstanceEdit:8852278] Orlic-Milacic, Marija, 2016-01-15
catalystActivity	[CatalystActivity:8853809] protein serine/threonine kinase activity of Mitotic kinase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8852310] Orlic-Milacic, Marija, 2016-01-15
edited	[InstanceEdit:8852278] Orlic-Milacic, Marija, 2016-01-15
input	[Complex:8852295] GTSE1:MAPRE1:microtubule plus end [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8852282] GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration
modified	[InstanceEdit:8852817] Orlic-Milacic, Marija, 2016-01-20 [InstanceEdit:8853810] Orlic-Milacic, Marija, 2016-01-25 [InstanceEdit:8853880] Orlic-Milacic, Marija, 2016-01-25 [InstanceEdit:8855169] Orlic-Milacic, Marija, 2016-02-01 [InstanceEdit:8862043] Orlic-Milacic, Marija, 2016-02-24 [InstanceEdit:9764017] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963936] Orlic-Milacic, Marija, 2025-08-18
name	Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends
output	[Complex:8852300] MAPRE1:microtubule plus end [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8852308] p-T513,T526-GTSE1 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:8852298] GTSE1 binds MAPRE1 (EB1) at microtubule plus ends [Homo sapiens] [Reaction:170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B [Homo sapiens] [Reaction:162657] Inactivation of Myt1 kinase [Homo sapiens] [Reaction:170120] Translocation of Cdc25B to the cytoplasm [Homo sapiens] [Reaction:170072] Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm [Homo sapiens]
releaseDate	2016-03-23
reviewed	[InstanceEdit:8855167] Bird, Alexander W, 2016-01-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861246] R-HSA-8852306.4
summation	[Summation:8852311] Starting in mitotic prometaphase, GTSE1 becomes phosphorylat...
(hasEvent)	[Pathway:8852276] The role of GTSE1 in G2/M progression after G2 checkpoint [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764037] Futile Cycle: Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends
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