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Details on Person Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus

Class:Id	Reaction:8852131
_displayName	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus
_doRelease	TRUE
_timestamp	2016-10-08 12:15:35
authored	[InstanceEdit:8852137] May, Bruce, 2016-01-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8852138] May, Bruce, 2016-01-13
edited	[InstanceEdit:8852137] May, Bruce, 2016-01-11
input	[SimpleEntity:29358] ATP [nucleoplasm] [Complex:8852095] Ub-Cys632-UBA1 [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8852041] Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging [LiteratureReference:8865061] Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent [LiteratureReference:8865039] Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown [LiteratureReference:8865067] Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation [LiteratureReference:8934565] Activating the ubiquitin family: UBA6 challenges the field
modified	[InstanceEdit:8865103] May, Bruce, 2016-03-20 [InstanceEdit:8865197] May, Bruce, 2016-03-21 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8933465] May, Bruce, 2016-08-04 [InstanceEdit:8934410] May, Bruce, 2016-08-09 [InstanceEdit:8934572] May, Bruce, 2016-08-11 [InstanceEdit:8942163] May, Bruce, 2016-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus
output	[Complex:8852059] Ub-Cys632-UBA1:ubiquitin adenylate [nucleoplasm] [Homo sapiens] [SimpleEntity:113541] PPi [nucleoplasm]
precedingEvent	[Reaction:8852136] UBA1 conjugates ubiquitin to UBA1 in the nucleus [Homo sapiens] [Reaction:8852128] UBA1 adenylates ubiquitin in the nucleoplasm [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8934570] Azevedo, Jorge E, 2016-08-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8900813] R-HSA-8852131.3
summation	[Summation:8865043] UBA1 is located in both the cytoplasm and nucleus (Grenfell ...
(hasEvent)	[Pathway:8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes [Homo sapiens]
(precedingEvent)	[Reaction:8852130] UBA1 conjugates ubiquitin to nuclear E2 enzymes [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782502] Update Tracker - [Reaction:8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - v59:[add_removeInput]
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