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Details on Person BTN2A2 protein is upregulated upon T cell activation and int...

Class:IdSummation:8851985
_displayNameBTN2A2 protein is upregulated upon T cell activation and int...
_timestamp2016-09-09 19:36:39
created[InstanceEdit:8851984] Garapati, Phani Vijay, 2016-01-12
literatureReference[LiteratureReference:8851972] BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation
[LiteratureReference:8938425] Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes
[LiteratureReference:8938466] Germline missense variants in the BTNL2 gene are associated with prostate cancer susceptibility
modified[InstanceEdit:8852015] Garapati, Phani Vijay, 2016-01-12
[InstanceEdit:8854887] Garapati, Phani Vijay, 2016-01-29
[InstanceEdit:8938435] Garapati, Phani Vijay, 2016-09-09
[InstanceEdit:8938496] Garapati, Phani Vijay, 2016-09-09
textBTN2A2 protein is upregulated upon T cell activation and interacts with activated T cells suggesting the presence of one or more receptors on these cells. It has been demonstrated that BTN2A2 inhibits T cell metabolism upon binding to its putative receptor on T cells (Smith et al. 2010).
(summation)[Reaction:8851988] BTN2A2 binds T cell surface [Homo sapiens]
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