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Details on Person SHC1-2 bound to MET recruits GRB2:SOS1

Class:Id	Reaction:8851900
_displayName	SHC1-2 bound to MET recruits GRB2:SOS1
_doRelease	TRUE
_timestamp	2016-07-19 17:47:25
authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8851898] Orlic-Milacic, Marija, 2016-01-11
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input	[Complex:8851891] HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8851883] The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18 [InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SHC1-2 bound to MET recruits GRB2:SOS1
output	[Complex:8851897] HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8851890] MET phosphorylates SHC1-2 [Homo sapiens] [Reaction:8851888] MET binds SHC1-2 [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8898771] R-HSA-8851900.2
summation	[Summation:8851901] SHC1 splicing isoform 2 (SHC1-2) phosphorylated by MET on ty...
(hasEvent)	[Pathway:8851805] MET activates RAS signaling [Homo sapiens]
(precedingEvent)	[Reaction:8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET [Homo sapiens]
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No pathways have been reviewed or authored by SHC1-2 bound to MET recruits GRB2:SOS1 (8851900)