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Details on Person MET phosphorylates SHC1-2

Class:IdReaction:8851890
_displayNameMET phosphorylates SHC1-2
_doReleaseTRUE
_timestamp2016-07-19 17:47:23
authored[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
catalystActivity[CatalystActivity:8851893] protein tyrosine kinase activity of HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:8851894] Orlic-Milacic, Marija, 2016-01-11
edited[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input[Complex:8851882] HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:8851883] The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein
modified[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18
[InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMET phosphorylates SHC1-2
output[SimpleEntity:29370] ADP [cytosol]
[Complex:8851891] HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2016-09-19
reviewed[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11
[InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8912324] R-HSA-8851890.2
summation[Summation:8851892] Activated MET receptor phosphorylates the splicing isoform 2...
(hasEvent)[Pathway:8851805] MET activates RAS signaling [Homo sapiens]
(precedingEvent)[Reaction:8851900] SHC1-2 bound to MET recruits GRB2:SOS1 [Homo sapiens]
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No pathways have been reviewed or authored by MET phosphorylates SHC1-2 (8851890)