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Details on Person Activated MET binds RANBP9 and SOS1

Class:Id	Reaction:8851859
_displayName	Activated MET binds RANBP9 and SOS1
_doRelease	TRUE
_timestamp	2016-07-19 17:47:21
authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8851854] Orlic-Milacic, Marija, 2016-01-11
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input	[Complex:6806977] HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:374586] RANBP9 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:64847] SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8851858] Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM [LiteratureReference:8851869] A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling
modified	[InstanceEdit:8851864] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8851881] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18 [InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated MET binds RANBP9 and SOS1
output	[Complex:8851860] HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:6806974] MET dimers autophosphorylate [Homo sapiens] [Reaction:6806957] MET receptor dimerizes [Homo sapiens]
regulatedBy	[NegativeRegulation:8851870] Negative regulation by 'HGF:p-4Y-MET dimer:RANBP10 [plasma membrane]'
regulationReference	[RegulationReference:9641943] Negative regulation by 'HGF:p-4Y-MET dimer:RANBP10 [plasma membrane]' A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling
releaseDate	2016-09-19
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8902722] R-HSA-8851859.4
summation	[Summation:8851862] RANBP9 binds to activated MET receptor and recruits RAS guan...
(hasEvent)	[Pathway:8851805] MET activates RAS signaling [Homo sapiens]
(precedingEvent)	[Reaction:8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET [Homo sapiens]
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