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Details on Person GRB2-1 is an adaptor protein for the RAS guanyl nucleotide e...
| Class:Id | Summation:8851831 |
|---|---|
| _displayName | GRB2-1 is an adaptor protein for the RAS guanyl nucleotide e... |
| _timestamp | 2016-01-11 18:37:31 |
| created | [InstanceEdit:8851830] Orlic-Milacic, Marija, 2016-01-11 |
| text | GRB2-1 is an adaptor protein for the RAS guanyl nucleotide exchange factor SOS1. GRB2-1, through association with activated receptor tyrosine kinases, such as MET, mediates recruitment of SOS1 to the plasma membrane. At the plasma membrane, SOS1 catalyzes guanyl nucleotide exchange on RAS proteins from GDP to GTP, resulting in RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997). |
| (summation) | [Reaction:8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 [Homo sapiens] |
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No pathways have been reviewed or authored by GRB2-1 is an adaptor protein for the RAS guanyl nucleotide e... (8851831)
