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Details on Person RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1

Class:Id	Reaction:8851827
_displayName	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
_doRelease	TRUE
_timestamp	2016-07-19 17:47:25
authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
catalystActivity	[CatalystActivity:8851826] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8851828] Orlic-Milacic, Marija, 2016-01-11
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
input	[SimpleEntity:29438] GTP [cytosol] [Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8851816] DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells [LiteratureReference:8851812] Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2
modified	[InstanceEdit:8851832] Orlic-Milacic, Marija, 2016-01-11 [InstanceEdit:8875937] Orlic-Milacic, Marija, 2016-06-09 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8931694] Orlic-Milacic, Marija, 2016-07-18 [InstanceEdit:8931945] Orlic-Milacic, Marija, 2016-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
output	[SimpleEntity:29420] GDP [cytosol] [Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8851804] Activated MET recruits GRB2-1:SOS1 [Homo sapiens] [Reaction:6806974] MET dimers autophosphorylate [Homo sapiens]
releaseDate	2016-09-19
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8905863] R-HSA-8851827.2
summation	[Summation:8851831] GRB2-1 is an adaptor protein for the RAS guanyl nucleotide e...
(hasEvent)	[Pathway:8851805] MET activates RAS signaling [Homo sapiens]
(precedingEvent)	[Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
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No pathways have been reviewed or authored by RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (8851827)