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Details on Person NTPDase7 hydrolyzes nucleoside triphosphates

Class:IdReaction:8851494
_displayNameNTPDase7 hydrolyzes nucleoside triphosphates
_doReleaseTRUE
_timestamp2025-12-11 22:36:04
authored[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
catalystActivity[CatalystActivity:8851507] ribonucleoside triphosphate phosphatase activity of NTPDase7:Ca2+ [endocytic vesicle membrane]
catalystActivityReference[CatalystActivityReference:9643824] nucleoside-triphosphatase activity of NTPDase7:Ca2+ [endocytic vesicle membrane] Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1)
compartment[Compartment:528865] endocytic vesicle lumen
[Compartment:24337] endocytic vesicle membrane
created[InstanceEdit:8851490] Orlic-Milacic, Marija, 2016-01-06
crossReference[DatabaseIdentifier:9976520] RHEA:19670
[DatabaseIdentifier:9976499] RHEA:64901
[DatabaseIdentifier:9976514] RHEA:29388
edited[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
input[DefinedSet:8851509] CTP,GTP,UTP [endocytic vesicle lumen]
[SimpleEntity:8851517] H2O [endocytic vesicle lumen]
isChimericFALSE
literatureReference[LiteratureReference:8851482] Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1)
[LiteratureReference:8851493] Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine
modified[InstanceEdit:8851522] Orlic-Milacic, Marija, 2016-01-06
[InstanceEdit:8851525] Orlic-Milacic, Marija, 2016-01-06
[InstanceEdit:8851530] Orlic-Milacic, Marija, 2016-01-06
[InstanceEdit:8870676] Orlic-Milacic, Marija, 2016-05-10
[InstanceEdit:8870677] Orlic-Milacic, Marija, 2016-05-10
[InstanceEdit:8870903] Orlic-Milacic, Marija, 2016-05-12
[InstanceEdit:8871616] Weiser, JD
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9737805] D'Eustachio, Peter, 2021-07-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
nameNTPDase7 hydrolyzes nucleoside triphosphates
CTP + H2O => CDP + phosphate + H(+)
GTP + H2O => GDP + phosphate + H(+)
UTP + H2O => UDP + phosphate + H(+)
output[DefinedSet:8851518] CDP,GDP,UDP [endocytic vesicle lumen]
[SimpleEntity:8851513] Pi [endocytic vesicle lumen]
[SimpleEntity:5228597] H+ [endocytic vesicle lumen]
releaseDate2016-06-15
reviewed[InstanceEdit:8870674] Sévigny, Jean, 2016-05-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8873462] R-HSA-8851494.6
summation[Summation:8851524] NTPDase7 (LALP1), encoded by the ENTPD7 gene, is a cytoplasm...
(hasEvent)[Pathway:8850843] Phosphate bond hydrolysis by NTPDase proteins [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775865] Update Tracker - [Reaction:8851494] NTPDase7 hydrolyzes nucleoside triphosphates - v78:[addOutput]
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