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Details on Person GPR143, also known as Ocular albinism 1 (OA1) binds L-dopami...

Class:IdSummation:8851300
_displayNameGPR143, also known as Ocular albinism 1 (OA1) binds L-dopami...
_timestamp2016-01-06 12:43:45
created[InstanceEdit:8851319] Jupe, S, 2016-01-06
literatureReference[LiteratureReference:8851293] The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis
[LiteratureReference:8851296] The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor
[LiteratureReference:8851289] The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii
[LiteratureReference:8851301] Melanin biosynthesis patterns following hormonal stimulation
[LiteratureReference:8851288] L-Dopa and the albino riddle: content of L-Dopa in the developing retina of pigmented and albino mice
[LiteratureReference:8851315] L-DOPA is an endogenous ligand for OA1
textGPR143, also known as Ocular albinism 1 (OA1) binds L-dopamine (L-Dopa) (Lopez et al. 2008, Hiroshima et al. 2014), the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) collectively known as catecholamines. L-Dopa is in intermediate of melanin biosynthesis (Aroca et al. 1993, Roffler-Tarlov et al. 2013). GPR143 is present on the apical cell surface of retinal pigment epithelial cells (Lopez et al. 2008). GPR143 can associate with several Galpha subunits, Gbeta and arrestin (Schiaffino & Tacchetti 2005, Innamorati et al. 2006). Its signalling is pertussis toxin sensitive and therefore likely to be mediated by Gq (Lopez et al. 2008).
(summation)[Reaction:8851298] GPR143 binds L-Dopa [Homo sapiens]
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