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Details on Person NTPDase3 hydrolyzes nucleoside triphosphates

Class:IdReaction:8851110
_displayNameNTPDase3 hydrolyzes nucleoside triphosphates
_doReleaseTRUE
_timestamp2025-12-11 22:35:57
authored[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
catalystActivity[CatalystActivity:8851106] ribonucleoside triphosphate phosphatase activity of NTPDase3:Ca2+,Mg2+ [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:8851112] Orlic-Milacic, Marija, 2016-01-05
crossReference[DatabaseIdentifier:9976523] RHEA:23681
edited[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
input[SimpleEntity:8870907] NTP [extracellular region]
[SimpleEntity:109276] H2O [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:8851120] Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1
[LiteratureReference:8870955] Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8
[LiteratureReference:8871000] Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3
[LiteratureReference:8870996] Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion
[LiteratureReference:8870994] Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors
modified[InstanceEdit:8851125] Orlic-Milacic, Marija, 2016-01-05
[InstanceEdit:8851526] Orlic-Milacic, Marija, 2016-01-06
[InstanceEdit:8870676] Orlic-Milacic, Marija, 2016-05-10
[InstanceEdit:8870677] Orlic-Milacic, Marija, 2016-05-10
[InstanceEdit:8870794] Orlic-Milacic, Marija, 2016-05-11
[InstanceEdit:8870903] Orlic-Milacic, Marija, 2016-05-12
[InstanceEdit:8871001] Orlic-Milacic, Marija, 2016-05-12
[InstanceEdit:8871002] Orlic-Milacic, Marija, 2016-05-12
[InstanceEdit:8871003] Orlic-Milacic, Marija, 2016-05-12
[InstanceEdit:8871019] Orlic-Milacic, Marija, 2016-05-12
[InstanceEdit:8871402] Orlic-Milacic, Marija, 2016-05-16
[InstanceEdit:8871616] Weiser, JD
[InstanceEdit:9737738] D'Eustachio, Peter, 2021-07-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
nameNTPDase3 hydrolyzes nucleoside triphosphates
a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + phosphate + H(+)
output[SimpleEntity:8870906] NDP [extracellular region]
[SimpleEntity:109277] Pi [extracellular region]
[SimpleEntity:351626] H+ [extracellular region]
releaseDate2016-06-15
reviewed[InstanceEdit:8870674] Sévigny, Jean, 2016-05-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8873496] R-HSA-8851110.5
summation[Summation:8851119] NTPDase3 (CD39L3), encoded by the ENTPD3 gene, is a plasma m...
(hasEvent)[Pathway:8850843] Phosphate bond hydrolysis by NTPDase proteins [Homo sapiens]
(precedingEvent)[Reaction:8851129] NTPDase3 hydrolyzes nucleoside diphosphates [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775610] Update Tracker - [Reaction:8851110] NTPDase3 hydrolyzes nucleoside triphosphates - v78:[addOutput]
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