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Details on Person Butyrophilin 2A1 (BTN2A1) can bind to a lectin molecule, DC-...

Class:IdSummation:8851052
_displayNameButyrophilin 2A1 (BTN2A1) can bind to a lectin molecule, DC-...
_timestamp2016-09-09 18:38:05
created[InstanceEdit:8851026] Garapati, Phani Vijay, 2016-01-05
literatureReference[LiteratureReference:8851037] The B7 homolog butyrophilin BTN2A1 is a novel ligand for DC-SIGN
[LiteratureReference:8857732] Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations
[LiteratureReference:8857777] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations
[LiteratureReference:8857768] Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome
[LiteratureReference:8851062] Immune modulation by butyrophilins
modified[InstanceEdit:8854887] Garapati, Phani Vijay, 2016-01-29
[InstanceEdit:8857785] Garapati, Phani Vijay, 2016-02-16
[InstanceEdit:8938435] Garapati, Phani Vijay, 2016-09-09
textButyrophilin 2A1 (BTN2A1) can bind to a lectin molecule, DC-specific ICAM3-grabbing non-integrin (DC-SIGN; also known as CD209), found on monocytes and dendritic cells. Binding of DC-SIGN is dependent on the tumor- and/or tissue-specific high-mannose glycosylation of BTN2A1 (Malcherek et al. 2007). BTN2A1 may represent a susceptibility gene for metabolic syndrome and myocardial infarction through an effect on dyslipidaemia (Fujimaki et al. 2011, Hiramatsu et al. 2012, Yamada et al. 2011, Arnett & Viney 2014).
(summation)[Reaction:8851018] BTN2A1 binds DC-SIGN [Homo sapiens]
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