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Details on Person Butyrophilin 3A1 (BTN3A1) directly binds to small pyrophosph...

Class:IdSummation:8851025
_displayNameButyrophilin 3A1 (BTN3A1) directly binds to small pyrophosph...
_timestamp2016-09-09 18:38:10
created[InstanceEdit:8851026] Garapati, Phani Vijay, 2016-01-05
literatureReference[LiteratureReference:8851024] The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells
[LiteratureReference:8854889] Regulation of Immunity by Butyrophilins
modified[InstanceEdit:8938435] Garapati, Phani Vijay, 2016-09-09
textButyrophilin 3A1 (BTN3A1) directly binds to small pyrophosphate containing organic molecules known as prenyl pyrophosphates or phosphoantigens (pAgs). These molecules are produced either endogenously, such as isopentenyl pyrophosphate (IPP), an intermediate of the mevalonate pathway in human cells that can accumulate intracellularly during tumorigenesis, or by microbes, such as hydroxy-methyl-butyl-pyrophosphate (HDMAPP, also known as HMBPP), a microbial intermediate of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. This interaction causes a conformational change in the extracellular domain of BTN3A1, which then leads to the activation of a specialized subset of gamma/delta T cells Vgamma9Vdelta2. The other two members of the BTN3A family, BTN3A2 and BTN3A3 may also be involved in the activation process (Sandstrom et al. 2014).
(summation)[Reaction:8851038] BTN3A1 binds prenylated phosphoantigens [Homo sapiens]
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