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Details on Person The major histocompatibility complex class I-related molecul...

Class:Id	Summation:8850373
_displayName	The major histocompatibility complex class I-related molecul...
_timestamp	2015-12-21 19:02:40
created	[InstanceEdit:8850371] Shamovsky, Veronica, 2015-12-19
literatureReference	[LiteratureReference:8850424] Antimicrobial activity of mucosal-associated invariant T cells [LiteratureReference:8850479] Human mucosal associated invariant T cells detect bacterially infected cells [LiteratureReference:8850376] MR1 presentation of vitamin B-based metabolite ligands [LiteratureReference:8850433] Recognition of vitamin B metabolites by mucosal-associated invariant T cells [LiteratureReference:8850423] T-cell activation by transitory neo-antigens derived from distinct microbial pathways [LiteratureReference:8850439] A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells [LiteratureReference:8850417] MR1 presents microbial vitamin B metabolites to MAIT cells [LiteratureReference:8850451] MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis [LiteratureReference:8850476] The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins [LiteratureReference:8850412] The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity [LiteratureReference:8850457] MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage [LiteratureReference:8850402] Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor
modified	[InstanceEdit:8850431] Shamovsky, Veronica, 2015-12-21
text	The major histocompatibility complex class I-related molecule MR1 can bind a novel class of antigens, namely a family of related small organic vitamin B metabolites (Kjer-Nielsen L et al. 2012; Corbett AJ, et al. 2014; Eckle SB et al. 2014; Patel O et al. 2013; McWilliam HE et al. 2015). When bound to MR1 these metabolites are presented to a population of innate-like T cells, mucosal-associated invariant T (MAIT) cells that express a semi-invariant T cell receptor (TCR) (Kjer-Nielsen L et al. 2012; Reantragoon R et al. 2012; Patel O et al. 2013; Eckle SB et al. 2014; Lopez-Sagaseta J et al. 2013; McWilliam HE et al. 2015). Several activating and non-activating MR1-restricted ligands have been described, which are the degradation products of, or intermediates of, vitamin B9 (folic acid) or vitamin B2 (riboflavin) (Corbett AJ, et al. 2014; Eckle SB et al. 2014). The MAIT-activating intermediates of the riboflavin synthesis pathway are unique to a wide range of microbes, and accordingly represent a molecular signature of microbial infection (Le Bourhis L et al. 2010; Gold MC et al 2010; 2014; 2015; Napier RJ et al. 2015).
(summation)	[Reaction:8850384] TCR binds microbial vitamin B metabolites-presenting MR1 [Homo sapiens]
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