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Details on Person Characterization of human INPP5F (SAC2) identified that it i...
| Class:Id | Summation:8849965 |
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| _displayName | Characterization of human INPP5F (SAC2) identified that it i... |
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| _timestamp | 2016-01-06 10:20:45 |
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| created | [InstanceEdit:8849956] Jupe, Steve, 2015-12-18 |
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| literatureReference | [LiteratureReference:8849961] Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness
[LiteratureReference:8850885] Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
[LiteratureReference:8850882] Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling |
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| modified | [InstanceEdit:8850884] Jupe, Steve, 2016-01-04
[InstanceEdit:8851285] Jupe, Steve, 2016-01-06 |
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| text | Characterization of human INPP5F (SAC2) identified that it is a 4-phosphatase with highest activity against PI(4,5)P2, PI(3,4)P2, and PI(3,4,5)P3, generating PI(5)P, PI(3)P and PI(3,5)P2 respectively (Nakatsu et al. 2015, Hsu et al. 2015). Inpp5f -/- mice have elevated level of PIP3 and exhibit accentuated cardiac hypertrophy as measured by heart size, myocyte size and gene expression (Zhu et al. 2009). |
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| (summation) | [Reaction:8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane [Homo sapiens] |
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