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Details on Person RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo

Class:Id	Reaction:8849348
_displayName	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo
_doRelease	TRUE
_timestamp	2016-02-19 18:21:50
authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:8849349] Rothfels, Karen, 2015-12-14
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
input	[Complex:8849251] RAB6:GTP [Golgi membrane] [Homo sapiens] [DefinedSet:8849329] COPI-independent Golgi-to-ER cargo [Golgi membrane] [Homo sapiens] [CandidateSet:8849243] BICD dimer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8849271] Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum [LiteratureReference:8849307] Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells [LiteratureReference:6811219] GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum [LiteratureReference:8849266] Biogenesis of tubular ER-to-Golgi transport intermediates [LiteratureReference:8849278] Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation [LiteratureReference:8849295] Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists [LiteratureReference:8849287] Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function [LiteratureReference:8849317] The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport [LiteratureReference:8849293] Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes [LiteratureReference:8849260] Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex [LiteratureReference:8849300] Rab6 and the secretory pathway affect oocyte polarity in Drosophila [LiteratureReference:6811242] Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A'
modified	[InstanceEdit:8851199] Rothfels, Karen, 2016-01-05 [InstanceEdit:8856712] Rothfels, Karen, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo
output	[Complex:8849334] RAB6:GTP:BICD dimer:COPI-independent retrograde cargo [Golgi membrane] [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861270] R-HSA-8849348.2
summation	[Summation:8849344] COPI-independent retrograde traffic from the Golgi to the ER...
(hasEvent)	[Pathway:6811436] COPI-independent Golgi-to-ER retrograde traffic [Homo sapiens]
(precedingEvent)	[Reaction:8849350] RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex [Homo sapiens]
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No pathways have been reviewed or authored by RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (8849348)