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Details on Person PTK6 phosphorylates AKT1

Class:Id	Reaction:8848758
_displayName	PTK6 phosphorylates AKT1
_doRelease	TRUE
_timestamp	2016-02-19 18:21:57
authored	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
catalystActivity	[CatalystActivity:8848755] protein tyrosine kinase activity of p-Y342-PTK6:AKT1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643083] protein tyrosine kinase activity of p-Y342-PTK6:AKT1 [cytosol] Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8848754] Orlic-Milacic, Marija, 2015-12-10
edited	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
input	[Complex:8848750] p-Y342-PTK6:AKT1 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8848752] Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor [LiteratureReference:8848767] Regulated association of protein kinase B/Akt with breast tumor kinase
modified	[InstanceEdit:8848770] Orlic-Milacic, Marija, 2015-12-10 [InstanceEdit:8856655] Orlic-Milacic, Marija, 2016-02-11 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PTK6 phosphorylates AKT1
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:8848769] p-Y342-PTK6:p-Y315,Y326-AKT1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8848751] PTK6 binds AKT1 [Homo sapiens] [Reaction:8848005] ERBB2 promotes PTK6 autophosphorylation [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861294] R-HSA-8848758.3
summation	[Summation:8848759] Activated PTK6 (BRK) phosphorylates AKT1 on tyrosine residue...
(hasEvent)	[Pathway:8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 [Homo sapiens]
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No pathways have been reviewed or authored by PTK6 phosphorylates AKT1 (8848758)