Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person PNPLA4 hydrolyzes TAG

Class:IdReaction:8848338
_displayNamePNPLA4 hydrolyzes TAG
_doReleaseTRUE
_timestamp2025-08-13 21:47:19
authored[InstanceEdit:8848345] D'Eustachio, Peter, 2015-12-07
catalystActivity[CatalystActivity:8848353] triacylglycerol lipase activity of PNPLA4 [cytosol]
catalystActivityReference[CatalystActivityReference:9643916] triglyceride lipase activity of PNPLA4 [cytosol] A comparative study of human GS2, its paralogues, and its rat orthologue
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:8848345] D'Eustachio, Peter, 2015-12-07
crossReference[DatabaseIdentifier:9958496] RHEA:12045
edited[InstanceEdit:8848345] D'Eustachio, Peter, 2015-12-07
input[SimpleEntity:549167] TAG [cytosol]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9958501] D'Eustachio, Peter, 2025-06-20
isChimericFALSE
literatureReference[LiteratureReference:8848343] A comparative study of human GS2, its paralogues, and its rat orthologue
[LiteratureReference:1482692] Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
modified[InstanceEdit:8854985] D'Eustachio, Peter, 2016-01-29
[InstanceEdit:8856684] D'Eustachio, Peter, 2016-02-11
[InstanceEdit:8980655] D'Eustachio, Peter, 2017-02-28
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9958494] D'Eustachio, Peter, 2025-06-20
[InstanceEdit:9958500] D'Eustachio, Peter, 2025-06-20
[InstanceEdit:9963237] D'Eustachio, Peter, 2025-08-13
namePNPLA4 hydrolyzes TAG
a triacylglycerol + H2O => a diacylglycerol + a fatty acid + H(+)
output[SimpleEntity:76103] DAG [cytosol]
[SimpleEntity:8876730] LCFA(-) [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8854946] Jassal, Bijay, 2016-01-29
[InstanceEdit:9963238] Hill, David P, 2025-08-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8861312] R-HSA-8848338.5
structureModified[InstanceEdit:9958494] D'Eustachio, Peter, 2025-06-20
summation[Summation:8848351] PNPLA4 (patatin-like phospholipase domain-containing protein...
(hasEvent)[Pathway:163560] Triglyceride catabolism [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781919] Update Tracker - [Reaction:8848338] PNPLA4 hydrolyzes TAG - v60:[add_removeInput, add_removeOutput]
[_UpdateTracker:9964695] Update Tracker - [Reaction:8848338] PNPLA4 hydrolyzes TAG - v94:[removeOutput]
[Change default viewing format]
No pathways have been reviewed or authored by PNPLA4 hydrolyzes TAG (8848338)
Follow Reactome