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Details on Person ACAT2 condenses 2 Ac-CoA to form ACA-CoA

Class:Id	Reaction:8848215
_displayName	ACAT2 condenses 2 Ac-CoA to form ACA-CoA
_doRelease	TRUE
_timestamp	2025-04-10 22:22:16
authored	[InstanceEdit:8848214] Jassal, Bijay, 2015-12-07
catalystActivity	[CatalystActivity:8848220] acetyl-CoA C-acetyltransferase activity of ACAT2 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8848214] Jassal, Bijay, 2015-12-07
crossReference	[DatabaseIdentifier:9945098] RHEA:21037
edited	[InstanceEdit:8848214] Jassal, Bijay, 2015-12-07
input	[SimpleEntity:76183] Ac-CoA [cytosol] [SimpleEntity:76183] Ac-CoA [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8848229] Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase [LiteratureReference:8848228] Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases
modified	[InstanceEdit:8848219] Jassal, Bijay, 2015-12-07 [InstanceEdit:8848222] Jassal, Bijay, 2015-12-07 [InstanceEdit:8848232] Jassal, Bijay, 2015-12-07 [InstanceEdit:8848278] Jassal, Bijay, 2015-12-07 [InstanceEdit:8866932] Jassal, Bijay, 2016-04-05 [InstanceEdit:8866934] Jassal, Bijay, 2016-04-05 [InstanceEdit:8871616] Weiser, JD [InstanceEdit:9734536] Jassal, Bijay, 2021-06-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10
name	ACAT2 condenses 2 Ac-CoA to form ACA-CoA 2 acetyl-CoA => acetoacetyl-CoA + CoA
output	[SimpleEntity:191293] ACA-CoA [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:75848] ACLY tetramer transforms CIT to Ac-CoA [Homo sapiens] [Reaction:75849] SLC25A1 exchanges CIT and MAL [Homo sapiens] [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX [Homo sapiens]
releaseDate	2016-06-15
reviewed	[InstanceEdit:8866933] D'Eustachio, Peter, 2016-04-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8873490] R-HSA-8848215.5
summation	[Summation:8848223] Three human enzymes, two mitochondrial and one cytosolic, ca...
(hasEvent)	[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971823] Update Tracker - [Reaction:8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - v95:[modifyText]
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