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Details on Person STAT3 binds SOCS3 promoter

Class:Id	Reaction:8848150
_displayName	STAT3 binds SOCS3 promoter
_doRelease	TRUE
_timestamp	2016-02-19 18:22:04
authored	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8848153] Orlic-Milacic, Marija, 2015-12-05
edited	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
input	[Complex:1112525] p-Y705-STAT3 dimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8848151] SOCS3 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8848142] Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes [LiteratureReference:8848160] STAT3-mediated constitutive expression of SOCS3 in an undifferentiated rat trophoblast-like cell line [LiteratureReference:8848169] Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors
modified	[InstanceEdit:8848175] Orlic-Milacic, Marija, 2015-12-05 [InstanceEdit:8856653] Orlic-Milacic, Marija, 2016-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STAT3 binds SOCS3 promoter
output	[Complex:8848152] p-Y705-STAT3 dimer:SOCS3 Gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2730599] Phosphorylated STAT3 Dimer Translocates to the Nucleus [Homo sapiens] [Reaction:2730595] Phosphorylated STAT3 Forms Dimers [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861318] R-HSA-8848150.2
summation	[Summation:8848159] The promoter of the SOCS3 gene contains two STAT binding/res...
(hasEvent)	[Pathway:8849474] PTK6 Activates STAT3 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8848178] STAT3 stimulates SOCS3 expression [Homo sapiens]
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No pathways have been reviewed or authored by STAT3 binds SOCS3 promoter (8848150)