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Details on Person SCD5 desaturates ST-CoA to OLE-CoA

Class:Id	Reaction:8847579
_displayName	SCD5 desaturates ST-CoA to OLE-CoA
_doRelease	TRUE
_timestamp	2024-03-20 19:03:07
authored	[InstanceEdit:8847577] D'Eustachio, Peter, 2015-11-30
catalystActivity	[CatalystActivity:8847576] stearoyl-CoA 9-desaturase activity of SCD5 dimer [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643204] stearoyl-CoA 9-desaturase activity of SCD5 dimer [endoplasmic reticulum membrane] Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:8847577] D'Eustachio, Peter, 2015-11-30
crossReference	[DatabaseIdentifier:9865944] RHEA:19722
edited	[InstanceEdit:8847577] D'Eustachio, Peter, 2015-11-30
input	[SimpleEntity:428139] ST-CoA [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:4085415] Fe(2+)Cb5 [cytosol] [SimpleEntity:4085415] Fe(2+)Cb5 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:8847582] Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates [LiteratureReference:8847578] Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells
modified	[InstanceEdit:8854947] D'Eustachio, Peter, 2016-01-29 [InstanceEdit:8856685] D'Eustachio, Peter, 2016-02-11 [InstanceEdit:8978914] D'Eustachio, Peter, 2017-02-20 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
name	SCD5 desaturates ST-CoA to OLE-CoA 2 Fe(II)-(cytochrome b5) + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-(cytochrome b5) + 2 H2O
output	[SimpleEntity:5690558] OLE-CoA [cytosol] [SimpleEntity:4085425] Fe(3+)Cb5 [cytosol] [SimpleEntity:4085425] Fe(3+)Cb5 [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:548831] TECR,TECRL dehydrogenate TOD-CoA to ST-CoA [Homo sapiens] [Reaction:5676637] PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8854946] Jassal, Bijay, 2016-01-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861319] R-HSA-8847579.5
summation	[Summation:8847585] Stearoyl-CoA desaturase 5 (SCD5, also known as acyl-CoA desa...
(hasEvent)	[Pathway:75105] Fatty acyl-CoA biosynthesis [Homo sapiens]
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